"Blood cholesterol levels between 200 and 240 mg/dl are normal. These levels have always been normal. In older women, serum cholesterol levels greatly above these numbers are also quite normal, and in fact they have been shown to be associated with longevity. Since 1984, however, in the United States and other parts of the western world, these normal numbers have been treated as if they were an indication of a disease in progress or a potential for disease in the future." (4)
Are you still not convinced that women should NOT take Statin Drugs? Don’t take my word for it. Take the word of Judith Walsh MD who wrote this in JAMA, 4 years ago in an article entitled, Treatment of Hyperlipidemia in Women:
"For women without cardiovascular disease, lipid lowering does not affect total or CHD (Cardiovascular Heart Disease) mortality. Lipid lowering may reduce CHD events, but current evidence is insufficient to determine this conclusively. For women with known cardiovascular disease, treatment of hyperlipidemia is effective in reducing CHD events, CHD mortality, nonfatal myocardial infarction, and revascularization, but it does not affect total mortality."(8)
Translation: Cholesterol lowering with statin drugs does not reduce total mortality in women, PERIOD. It doesn’t reduce mortality in women without heart disease, called primary prevention. It doesn’t reduce mortality in women with heart disease, called secondary prevention.
Still not convinced? then read this article by Malcolm McKendrick, a doctor in England, in the British Medical Journal, May 2007, entitled: "Should Women be Offered Cholesterol Lowering Drugs? NO ".(8A)
"To date, none of the large trials of secondary prevention with statins has shown a reduction in overall mortality in women. Perhaps more critically, the primary prevention trials have shown neither an overall mortality benefit, nor even a reduction in cardiovascular end points in women. This raises the important question whether women should be prescribed statins at all. I believe that the answer is clearly no."(8A)
Note: Secondary prevention means women with known heart disease. Primary prevention means women without known heart disease.
Still not convinced ? Then read this June 2007 article by Electra Kaczorowski, of the National Women’s Health Network:
"There is currently no indication that women of any age or any risk level will benefit from taking statins to prevent CHD and other heart conditions – yet this is precisely how statins are being marketed to women. " (9)
Still not convinced ? Are statin drugs good for anybody? Read this review article by Joel Kauffman PhD, Dec 2003, in which the best statin trial results (the HPS simvastatin study) had an absolute reduction of all cause death rate of 0.38% per year. Yet this performance was inferior to the less expensive alternatives of buffered aspirin or Omega-3 oils.(10,10a)
Quote:
"The most favorable (statin) trial with seemingly impeccable reporting and minimal financial conflict of interest was the Heart Protection Study (HPS), on simvastatin for 5 years, in which secondary prevention in men (86% of patients) of any unwanted vascular event gave a RR = 0.76 (5.5% absolute, 1.1% per year), and an all-cause death rate drop of 0.38% per year. (Lancet 2002; 360:7-22).
Since this performance is inferior to that of either Bufferin in men or omega-3 fatty acid supplements, both of which have lesser side-effects, and are far less expensive, the logic of prescribing simvastatin seems faulty." (10,10a)
Still not convinced ? Then read this article by Harriett Rosenberg from Women and Health Protection from June 2007, Do Cholesteriol Lowering Drugs Benefit Women ? (11) Evidence for Caution: Women and statin use By Harriet Rosenberg Danielle Allard Women and Health Protection June 2007
Quote: "Our review of these fields identifies a troubling disjuncture between the widespread use of statin medication for women and the evidence base for that usage. What we found instead was evidence for caution."
Still not convinced ? Not only are statin drugs a failure for women, they also should never be prescribed to the elderly. Mortality in the elderly goes up as cholesterol goes down. Read this Letter to the Editor by Eddie Vos. (12)
Quote:"Regarding women, two 2004 analysis found no reduction in deaths from statin over placebo. In actual patient outcomes, the J-Lit study in 41,801 hypercholesterolemic Japanese (2/3rds women) found mortality in the 2 lowest on-statin cholesterol categories 2-3 times higher; its authors cautioned about ‘hyperresponders’ to statin. The 4S study ended with 3 more dead women on statin vs. placebo, and another ‘successful’ study, HPS, found no significant mortality benefit in women." (See article for references.)
Still not convinced ? Then read this article by Bill Sardi, Who Will Tell the People? It Isn't Cholesterol ! (13)
"If physicians were truly honest with their patients, there probably would be very few people being treated for primary prevention with a statin drug."
Still not convinced? Then read this Jan 2007 Lancet article by Harvard trained MD, John Abramson, "Are lipid-lowering guidelines Evidence-Based ? ". (14)
Quote:" No studies have shown statin cholesterol-lowering drugs to be effective for women at any age, nor for men 69 years of age or older, who do not already have heart disease or diabetes. Better than 50 adults have to take a cholesterol-lowering drug for 1 patient to avoid a mortal heart attack, and that figure only applies to high-risk patients. There is a vanishing benefit to lowering cholesterol for healthy adults." [Lancet 2007; 369:168-169].
Dr. John Abramson joins with 30 more eminent MD's in this Sept 2004 letter to the NIH calling for a complete revision of the faulty cholesterol treatment guidelines.
Still not convinced? Then read this e-book by Shane Ellsion, "The Hidden Truth About Cholesterol-Lowering Drugs! ", by Shane Ellison, MS, Organic Chemistry. (15)
"Among healthy people, statin drugs do not prevent early death from heart disease, despite their cholesterol lowering effects. This is because there is no correlation or relationship between low cholesterol and the progression of atherosclerosis – the number one cause of heart disease. Repeat that sentence. This became abundantly clear with the statin drug trials." Quote from Shane Ellison (15)
More Articles with Related Interest:
Reversing Heart Disease with DeToxMax Plus and Lipophos EDTA
Heart of the Matter, Maryanne Demasi, the Cholesterol Myth-Video Series
39 Reason to Avoid Stenting and Bypass
Vitamin E, Heart Disease and Tocotrienols
Calcium Tablets Cause Heart Disease
Saving Time Russert and George Carlin
Healthy Men Should Not Take Statin Drugs
Heart Disease Vitamin C and Linus Pauling
Getting Off Statin Drug Stories
How to Reverse Heart Disease with the Coronary Calcium Score (part one)
Reversing Heart Disease Part Three
Cholesterol Lowering Drugs for the Elderly, Bad Idea
Cholesterol Lowering Statin Drugs for Women Just Say No
(1) http://www.postgradmed.com/issues/2002/08_02/pearlman.shtml
The new cholesterol guidelines, Applying them in clinical
practice Brian L. Pearlman, MD, FACP VOL 112 / NO 2 / AUGUST 2002 /
POSTGRADUATE MEDICINE
(2) http://www.nhlbi.nih.gov/guidelines/cholesterol/atglance.htm
The new cholesterol guidelines . Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
(3) http://www.usatoday.com/news/health/2004-10-16-panel-conflict-of-interest_x.htm
USA Today, 2004, Cholesterol guidelines become a morality play the Associated Press
(4) http://www.westonaprice.org/health-topics/cholesterol-and-heart-disease-a-phony-issue/
Mary Enig, Cholesterol and Heart Disease-- A Phony Issue
(5) http://www.cmaj.ca/cgi/content/full/173/10/1207-a
Questioning the benefits of statins Eddie Vos and Colin P. Rose , CMAJ • November 8, 2005; 173 (10). doi:10.1503/cmaj.1050120.
(6) http://www.westonaprice.org/moderndiseases/statin.html
Dangers of Statin Drugs: What You Haven’t Been Told About
Popular Cholesterol-Lowering Medicines By Sally Fallon and Mary G.
Enig, PhD
(7) http://www.ti.ubc.ca/pages/letter48.htm
Therapeutics Initiative, Do Statins have a Role in
Primary Prevention? There were 10,990 women in the primary prevention
trials (28% of the total). Only coronary events were reported for women,
but when these were pooled they were not reduced by statin therapy, RR
0.98 [0.85-1.12]. Thus the coronary benefit in primary prevention trials
appears to be limited to men, RR 0.74 [0.68-0.81], ARR 2.0%, NNT 50 for
3 to 5 years.
(8) http://jama.ama-assn.org/cgi/content/abstract/291/18/2243
Drug Treatment of Hyperlipidemia in Women Judith M. E. Walsh, MD, MPH; Michael Pignone, MD, MPH JAMA. 2004;291:2243-2252.
(8A) http://www.bmj.com/cgi/content/full/334/7601/983
BMJ 2007;334:983 (12 May),
doi:10.1136/bmj.39202.397488.AD Should women be offered cholesterol
lowering drugs to prevent cardiovascular disease? No Malcolm Kendrick,
general practitioner
(9) https://nwhn.org/exploring-statins-what-does-evidence-say
Women's Health Activist May/ June 2007: Exploring
Statins: What Does the Evidence Say? By Electra Kaczorowski, National
Women’s Health Network
(10) http://www.laleva.org/eng/2004/04/statin_drugs_a_critical_review_of_the_riskbenefit_clinical_research.html
Statin Drugs: A Critical Review of the Risk/Benefit
Clinical Research, Joel M. Kauffman, Ph.D. Professor of Chemistry
Emeritus USP Philadelphia, PA, USA 9 Dec 2003
10a) Statin Drugs by Joel M. Kauffman.pdf
265.4 KB
Misleading Recent Papers on Statin Drugs in Peer-Reviewed Medical Journals by Joel M. Kauffman, Ph.D. Journal of American Physicians and Surgeons Volume 12 Number 1 Spring 2007
(11) http://www.whp-apsf.ca/pdf/statinsEvidenceCaution.pdf
Evidence for Caution: Women and statin use By Harriet Rosenberg Danielle Allard Women and Health Protection June 2007
(12) http://www.health-heart.org/malpractice.pdf
LETTER TO THE EDITOR: Statins for women, elderly:
Malpractice? Nutrition, Metabolism & Cardiovascular Diseases (2007)
17, e19ee20 Eddie Vos 127 Courser Rd, Sutton (Qc),
(13) http://www.lewrockwell.com/sardi/sardi69.html
Who Will Tell the People? It Isn't Cholesterol! by Bill Sardi
(14) http://www.overdosedamerica.com/2007/03/lancet-article-are-lipid-lowering.html
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2807%2960084-1/fulltext
Lancet: Vol 369 January 20, 2007 Are lipid-lowering guidelines evidence-based? J Abramson and JM Wright
(15) Hidden Truth Cholesterol-Lowering Drugs Shane Ellison,.pdf
472.2 KB
The Hidden Truth About Cholesterol-Lowering Drugs, by Shane Ellison, MS, Organic Chemistry
(16) http://www.nytimes.com/2008/01/17/business/17drug.html
New Questions on Treating Cholesterol, By ALEX BERENSON, New York Times January 17, 2008
(18) http://www.lewrockwell.com/sardi/sardi79.html
Government Health Agencies Complicit in Cholesterol Ruse by Bill Sardi on Lew Rockwell.com
(19) deleted
(20) http://blogs.wsj.com/health/2008/01/14/zetia-doesnt-enhance-zocor/
January 14, 2008, 9:11 am Zetia Doesn’t Enhance Zocor Posted by Shirley S. Wang Wall Street Journal
(21) //www.youtube.com/watch?v=kBfWybm0218
Vytorin video AD on You Tube 30 sec, Humorous clothes which look like the food.
These adds have been pulled from natiuonal television.
(22) http://energycommerce.house.gov/Press_110/110-ltr.010708.Pfizer.Jarvik.pdf
Letter from John Dingel Mich to CEO of Pfizer asking for records on Jarvik and Lipitor, celebrity endorsement of Lipitor Ads.
(22a) http://blogs.wsj.com/health/2008/01/16/congress-investigates-vytorin-ads/
Wall Street Journal January 16, 2008, 3:44 pm Congress Investigates Vytorin Ads Posted by Anna Wilde Mathews
(23) http://blogs.wsj.com/health/2008/01/07/congress-to-pfizer-why-is-robert-jarvik-the-lipitor-man/
January 7, 2008, Wall Street Journal, Congress to Pfizer: Why is Robert Jarvik the Lipitor Man? Posted by Shirley S. Wang
(24) You Tube Lipitor Ads with Robert Jarvik
(25) http://www.nytimes.com/2008/01/17/business/17drug.html
New Questions on Treating Cholesterol By ALEX BERENSON Published: January 17, 2008
(27) http://www.jpands.org/vol10no3/colpo.pdf
LDL Cholesterol, Bad Cholesterol or Bad Science by
Anthony Colpo, Journal of American Physicians and Surgeons Volume 10
Number 3 Fall 2005
(28) http://www.joplink.net/prev/200411/200411_10.pdf
Recurrent Acute Pancreatitis Possibly Induced by Atorvastatin and Rosuvastatin. Is Statin Induced Pancreatitis a Class Effect? JOP. J Pancreas (Online) 2004; 5(6):502-504.
(29) http://www.cmellc.com/geriatrictimes/g040618.html
Statin Adverse Effects: Implications for the Elderly by
Beatrice A. Golomb, M.D., Ph.D. Geriatric Times May/June 2004 Vol. V
Issue 3. "No survival benefit with statin drugs is seen in elderly
patients at high risk for cardiovascular disease (Shepherd et al.,
2002). For patients older than 85, benefits may be more attenuated and
risks more amplified (Weverling-Rijnsburger et al., 1997). In fact, in
this older group, higher cholesterol has been linked observationally to
improved survival.
(30) http://www.bmj.com/cgi/content/full/335/7614/285
Preventive health care in elderly people needs
rethinking, BMJ 2007;335:285-287 (11 August), "Preventive use of
statins shows no overall benefit in elderly people as cardiovascular
mortality and morbidity are replaced by cancer".
(31) http://image.thelancet.com/extras/02art8325web.pdf
Pravastatin in elderly individuals at risk of (PROSPER): a
randomised controlled trial. THE LANCET • Published online November 19,
2002 •
(32) http://www.spacedoc.net/index.html
SpaceDoc, Duane Graveline MD Autho of Statin Drugs Side Effects
(33) http://www.thincs.org/index.htm
THINCS THe International Society of Cholesterol Sceptics
(34) http://www.jpands.org/vol12no1/kauffman.pdf
Misleading Recent Papers on Statin Drugsin Peer-Reviewed
Medical Journals Joel M. Kauffman, Ph.D. Journal of American Physicians
and Surgeons Volume 12 Number 1 Spring 2007
(35) http://www.scientificexploration.org/jse/articles/pdf/18.4_bauer.pdf
Science in the 21st Century: Knowledge Monopolies and Research Cartels. HENRY H. BAUER Professor Emeritus of Chemistry & Science Studies
Dean Emeritus of Arts & Sciences Virginia Polytechnic Institute
& State University / Journal of Scientific Exploration, Vol. 18, No.
4, pp. 643–660, 2004
(36) http://www.ajronline.org/cgi/reprint/151/4/667
Radiologic Appearance of the Jarvik Artificial Heart
Implant Its Thoracic Complications AJR 151:667-671, October 1988 Laurie
L. Fajardo
(37) http://query.nytimes.com/gst/fullpage.html?res=9A0DE0DC1F3FF93AA15755C0A960948260
The End of Life: Euthanasia and Morality (Oxford University Press, 1986).] SUICIDE AND EUTHANASIA Barney Clark’s key to turn off artificial heart.
(38) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014585/
Statins for primary prevention: at what coronary risk is safety assured? Peter R Jackson Br J Clin Pharmacol. 2001 October; 52(4): 439–446. For
people with no known heart disease (primary prevention), "statin use
could be associated with an increase in mortality of 1% in 10 years."
Jeffrey Dach MD
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